• Thursday 31 May 2018
  • Scientific Session 3: Vascular Malformations 2

    Moderator: Miikka Vikkula
    • 08:00
      O028 Endothelial Cell Lineage Tracing in Cerebral Cavernous Malformations: A Modification of the “Two-Hit” Mutation Model of CCM Pathogenesis.

      Matthew Detter and Douglas Marchuk
    • 08:09
      O029 Rapamycin not shown to inhibit LM growth in a mouse xenograft model.

      Tony Penington, Zerina Lokmic and Nerida Sleebs
    • 08:18
      O030 Activation Of AKT In Tissue Endothelial Cells & Elevated Serum ANG-2 levels in Patients With Capillary Lymphatic Venous Malformations

      Tim LeCras, Jillian Goines, patricia pastura, Paula Mobberley-Schuman, Megan Metcalf, Denise Adams, Adrienne Hammill and Elisa Boscolo
    • 08:27
      O031 Laser Ablation of Lymphatic Malformation Using Nanoparticle Targeted Therapy

      Ravi Sun, Ekaterina Galanzha, Dmitry Nedosekin, Haihong Zhang, Ting Wei, Zerina Lokmic, June Wu, Tony Penington, Vladimir Zharov and Gresham Richter
    • 08:36
      O032 Excessive PI3K/mTOR signaling causes lymphatic hyperplasia and dysfunction in mice

      Devon Hominick, Noor Khurana, Lara Rodriguez-Laguna, Noelia Agra, Gema Gordo, Pablo Lapunzina, Juan C. Lopez-Gutierrez, Victor Martinez-Glez and Michael Dellinger
    • 08:43
      O033 Gene Expression Detected in Peripheral Blood of Patients with Lymphatic Malformation

      Joyce Teng, Kavita Sarin, Taehan Kim, Ramie Lekwuttikan, Elidia Tafoya and Malcolm Chelliah
    • 08:50
      O034 Superficial Cutaneous Vascular Malformations and Other Skin Manifestations of the PIK3CA-Related Overgrowth Spectrum (PROS)

      Justine Pasteur, Paul Kuentz, Yannis Duffourd, Arthur Sorlin, Laurence Faivre, Christelle Thauvin, Jean-Baptiste Rivière, Pierre Vabres and Investigators of MUSTARD Cohort
    • 08:57
      O035 The full spectrum of post-zygotic PIK3CA mutations in non-syndromic lymphatic malformations

      James Bennett, Chi Cheng, Dana Jensen, Andrew Timms, Sheila Ganti, Giri Shivaram, Randall Bly, Andrew Kirsh, William Dobyns, Mark Makesky and Jonathan Perkins
    • 09:04
      O036 Activating mutations in PIK3CA are specifically localized in lymphatic malformation-derived lymphatic endothelial cells of young children: therapeutic implications

      Jochen Rössler, Hannah Blesinger, Juergen Becker, Silke Kaulfuss and Jörg Wilting
    • 09:11
      O037 Safety and Efficacy of Low Dose Sirolimus in Patients with PIK3CA-Related Overgrowth

      Victoria Parker, Kim M. Keppler-Noreuil, Pierre Vabres, Leena De Silva, Julie C. Sapp, Maxime Luu, Marjorie J. Lindhurst, Elodie Gautier, Marc Bardou, Laurence Faivre, Robert Semple and Leslie G. Biesecker
    • 09:18
      O038 Segmental Overgrowth in Syndromic Vascular Anomalies: Towards a Pharmacogenetic Therapy with Rapamycin

      V. Baraldini, L. Spaccini , E. Cattaneo , D. Graziani, L. Moneghini, G. Bulfamante
    • 09:25
      O039 “PTEN hamartoma of soft tissue” may also be related to PIK3CA mutations.

      Olivia Boccara, Louise Galmiche-Rolland, Bérengère Dadone, Stéphanie Pannier, Véronique Soupre, Florence Pedeutour and Sylvie Fraitag
    • 09:32
      O040 How to build a multi-disciplinary vascular anomalies clinic from scratch: Lessons learned from a large, tertiary-care American children’s hospital

      C. Matthew Hawkins, Steven Goudy, Michael Briones, Rachel Swerdlin, Jonathan Meisel, Sarah Milla, Magdalena Soldanska and Leslie Lawley
    • 09:39
      O041 A FAIR compliant registry for the vascular malformation centres within the European Reference Networks. How it was done

      Leo Schultze Kool, Alan IRVINE, Päivi Salminen, Nader Ghaffarpour, Andrea Diociaiuti, Jochen Rössler, C.T. van den Bosch, Eulalia Baselga, Anne Dompmartin, Laurence Boon, Miikka Vikkula, Luiz Bonino, Mark Thompson, Annika Jacobsen, David van Enckevort and Marco Roos
    • 09:46
      O042 The European Reference Network (ERN) criteria for multidisciplinary vascular anomaly clinics (VASCA) in the VASCERN

      Jochen Rössler, Eulalia Baselga, Laurence Boon, Andrea Diociaiuti, Anne Dompmartin, Nader Ghaffarpour, Alan D Irvine, Paivi Salminen, Leo SchultzeKool, Caroline van den Bosch and Miikka Vikkula
    • 09:54
      O043 Patient involvement on vascular anomalies in the European Reference Network VASCERN

      C.T. van den Bosch, Matt Bolz-Johnson, Miikka Vikkula, Leo Schultze Kool, Jochen Rössler, Eulalia Baselga, Laurence Boon, Andrea Diociaiuti, Anne Dompmartin, Nader Ghaffarpour, Alan Irvine, Päivi Salminen, Maria Barea, Ange van der Velden and Petra Borgar
  • 10:00
    Coffee Break
  • Difficult Cases 2

    Moderators: Juan Carlos Lopez-Guttierez & Denise Adams
    • 10:30
      O044 Syndromic segmental arterio-venous malformation: a therapeutic challenge

      Olivia Boccara, Annouk Bisdorff Bresson, Diala Khraiche, Olivier Naggara, Timothée de Saint-Denis, Paul Kuentz, Smail Hadj-Rabia, Francis Brunelle and Stéphanie Pannier
    • 10:39
      O045 A difficult case of upper limb venous malformation with intolerance to oral sirolimus

      Mei-Yoke Chan, Luke Toh and Mark Koh
    • 10:48
      O046 Management challenges of a complex CLOVES Syndrome patient with severe scoliosis and lipomatous overgrowth

      Wesley Barry, Donna Nowicki, Minnelly Luu, Chadi Zeinati, Lori Howell and Dean Anselmo
    • 10:57
      O047 Case Report: Management of Menorrhagia in a Young Woman with Blue Rubber Bleb Nevus Syndrome: Failures and Successes

      Carrie Terrell, Sheilagh Maguiness and Brenda Weigel
  • Scientific Session 4: Vascular Malformations 3

    Moderators: Gerald M. Legiehn & David Lord
    • 11:10
      O048 Prevalence of Cardiac Failure in Patients with Arteriovenous Malformations

      Megan Gaffey, Megan Scarbrough, Ravi Sun, Joseph Deloach, James Suen and Gresham Richter
    • 11:19
      O049 PET/CT imaging of angiogenesis in arteriovenous malformations

      Daphne Lobeek, Mark Rijpkema, Miikka Vikkula, Laurence Boon, Frédérique Bouwman, Willemijn Klein, Erik Aarntzen and Leo Schultze Kool
    • 11:26
      O050 Melorheostosis and vascular anomalies caused by somatic mosaicism of KRAS

      Minia Campos-Domínguez, Víctor Martínez-Glez, Verónica Seidel, Teresa Martínez-Menchón, Belén Ferri Ñiguez, Antonio Cervantes Pardo, Ángel Lancharro-Zapata, Yolanda Ruiz-Martín, Antonio Salcedo-Posadas, Jorge Huerta-Aragonés, Carmen Garrido-Colino, Beatriz Berenguer-Fröhner, Elena De Tomás-Palacios, Concepción Lorca-García and Rosario García-Pajares
    • 11:33
      O051 Extracranial Arteriovenous Malformations (AVMs) Are Caused by Activating MAP2K1 Mutations In Endothelial Cells

      Javier A. Couto, August Yue Huang, Patrick J. Smits, Dennis J. Konczyk, Jeremy A. Goss, Steven J. Fishman, John B. Mulliken, Matthew L. Warman, Arin K. Greene
    • 11:43
      O052 Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

      Satyamaanasa Polubothu, Mary Glover, Lara Al-Olabi, Katherine Dowsett, Katrina Andrews, Paulina stadnik, Agnel P Joseph, Rachel Knox, Alan Pittman, Graeme Clark, William Baird, Neil Bulstrode, Kristiana Gordon, Darren Hargrave, Sue Huson, Thomas Jacques, Gregory James, Hannah Kondolf, Loshan Kangesu, Kim Keppler-noreuil, Amjad Khan, Marjorie Lindhurst, Mark Lipson
    • 11:52
      O053 The Role of Notch Pathway Components in Extracranial Arteriovenous Malformations

      Ting Wei, Haihong Zhang, Ravi Sun and Gresham Richter
  • 12:00
    Lunch & Poster Presentations P059-P144 & P157-P190

  • Scientific Session 5: Hemangiomas and Vascular Tumors

    Moderators: Eulalia Baselga & Maria Garzon
    • 13:30
      O054 Source of Elevated AFP Levels in Infantile Haemangioma

      Tinte Itinteang, Matthew Munro, Bede van Schaijik, Jennifer de Jongh, Erin Paterson, Reginald Marsh and Swee Tan
    • 13:37
      O055 Resistance Index (RI) in Colour Coded Duplex Sonography (CCDS) Easy Use and Reliable Results in the Determination of Activity in Infantile Hemangiomas

      Peter Urban
    • 13:44
      O056 Non-involuting congenital hemangiomas (NICH) with post-natal atypical growth: a case series

      Maria Cossio, Josee Dubois, Catherine McCuaig, Danielle Marcoux, Sandra Ondrejchak and Julie Powell
    • 13:51
      O057 Tardive Expansion Congenital Hemangioma: a variation of NICH or a new hemangiomatous entity?

      Chen Hua, Yunbo Jin, Lizhen Wang, Hui Chen, Gang Ma, Yajing Qiu and Lin Xiaoxi
    • 13:58
      O058 Use of the Hemangioma Severity Scale to facilitate treatment decisions for infantile hemangiomas

      Carine Van der Vleuten and Andre Moyakine
    • 14:07
      O059 Multiple cutaneous and visceral GLUT-1 positive congenital vascular tumors: a novel entity or a variant of multifocal infantile hemangiomatosis.

      Esperanza Mantilla-Rivas, Pamela Tan, Jocelyn C Zajac, Alexandra Tilt, Nancy Bauman, Philip Guzzetta, Gina Krakovsky, Bhupender Yadav, Ana Yasmine Kirkorian and Albert Oh
    • 14:14
      O060 Systemic Timolol Exposures Following Topical Application to Infantile Hemangiomas

      Beth Drolet, Felix Boakye-Agyeman, Sarah Chamlin, Scott Denne, Anita Haggstrom, Barrie Harper, Kristen Holland, Jan Hau Lee, Hui Min Liew, Andrew Lewandowski, Casey Gelber, Anthony Mancini, Dawn Siegel, Nicole Stefanko, Rami Yogev and Chiara Melloni
    • 14:23
      O061 Efficacy and Safety of Topical Timolol Maleate 0.5% Solution for Infantile Hemangioma in Early Proliferative Phase. A Randomized Clinical Trial

      Fania Muñoz Garza, Mónica Ríos Varela, Esther Roé Crespo, Lluis Puig Sanz, José Bernabeu Wittel and Eulalia Baselga Torres
    • 14:32
      O062 Utility of Prolonged Monitoring During Initiation of Oral Propranolol for Infantile Hemangioma

      Leanna Hansen, Denise Adams, Eulalia Baselga Torres, Sarah Chamlin, Kristen Corey, Flora Frascari, Ilona Frieden, Peter Frommelt, Eloise Galligan, Maria Garzon, Kimberly Horii, Justyna Klajn, Christine Lauren, Anthony Mancini, Diana Mannschreck, Erin Mathes, Anelah McGinness, Brandon Newell, Henry Nguyen, Amy Nopper, Tola Oyesanya, Kate Puttgen, Megan Reynolds, Dawn Siegel, Nicole Stefanko, Megha Tollefson and Beth Drolet
    • 14:39
      O063 AQP1 plays a key role in propranolol response in vivo

      Francois Moisan, Priscilla Kaulanjan, Sorilla Prey, Maya Loot, Christine Léauté Labreze, Alain Taieb and Hamid Rezvani
    • 14:46
      O064 Propranolol treatment does not affect growth and development of children with infantile hemangioma

      Andre Moyakine
    • 14:53
      O065 Hemangioma Sequelae In Infantile Hemangiomas Treated With Propranolol

      Eulalia Baselga, may el hachem, Andrea Diociaiuti, Claudia Carnevale, Camila Downey, Esther Roe, Iria Neri, Miriam Leuzzi, Jose Bernabeu-Wittel, M Teresa Montserrat-Garcia, Alejandro Ortiz-Prieto, antonio torrelo, Nicole Knopfel, Nadia Vercellino, Francesca Manunza, M Antonia Gonzalez-Enseñat, M Asuncion Vicente-Villa and ignasi Gich
    • 15:00
      O066 The positive predictive value of hemangioma location for risk of PHACE syndrome: a retrospective analysis

      Colleen Cotton, Jusleen Ahluwalia, Ilona Frieden, Leslie Castelo-Soccio, Elena Pope, Dawn Siegel, Esteban Fernandez-Faith, Kim Morel, Christine Lauren, Maria Garzon, Anthony Mancini, Sarah Chamlin, Anita Haggstrom, Megha Tollefson, Marilyn Liang, Sharon G
    • 15:07
      O067 Sternal/Midline Anomalies in PHACE Syndrome

      Nicole Stefanko, Beth Drolet, Olayemi Sokumbi, Ilona Frieden, Renee Howard, Juan Carlos Lopez Gutierrez, Maria Garzon, Eloise Galligan, Denise Metry, Francine Blei, Janet Fairley, Deborah Goddard and Dawn Siegel
  • 15:15
    Coffee Break
  • Difficult Cases 3

    Moderators: Beth Drolet & Lisa Weibel
    • 15:45
      O068 Necrotizing Infection of an Infantile Hemangioma: An Uncommon Complication of a Common Disorder

      Bridget Shields, Lauren Brin Hermans, Beverly Aagaard-Kienitz, David Wargowski, Darya Buehler, Jason Pinchot, Carrie Kovarik, Lisa Arkin and Catharine Garland
    • 15:54
      O069 Primary Hepatic Angiosarcoma in a 3 year-old Child Complicated by Consumptive Hypothyroidism: A Case Report

      Lara Mrak, Michael Woods, Carol Diamond, Jason Pinchot, Beverly Aagaard Kienitz, Lisa Arkin, Paula North, Darya Buehler and Kara Gill
    • 16:03
      O070 Controversy RICH or KHE? What constitutes a true Kasabach Merritt syndrome? Necrotizing fasciitis in vascular anomalies: Seeking other centers experience, prevention?

      Catherine McCuaig, Michele David, Patricia Bortoluzzi, Louise Laberge, Elizabeth Rousseau, Afshin Hatami, Sandra Ondrejchak and Josée Dubois
    • 16:12
      O071 Fatal hemorrhage from a rapidly involuting congenital hemangioma in an infant

      Aicha Salhi, Warda Drali, Nora Cheddani, Toufik Tounsi, Assya Djeridane, Abdelhamid Aitbenamar, Zoheir Belkaid and Ismail Benkaidali
  • 19:00
    Social Event - Congres Dinner (ticketed)